WNT and GSK3 Signaling Pathways in Bipolar Disorder: Clinical and Therapeutic Implications. Clinical Psychopharmacology and Neuroscience

Probing the lithium-response pathway in hIPSCs implicated the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis. PNAS

Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia. Nature Genetics

Restoring WNT/beta-catenin signaling is a promising therapeutic strategy for Alzheimer’s Disease. Molecular Brain

APOE3 Christchurch modulates tau phosphorylation and β-catenin/Wnt/Cadherin signaling in induced pluripotent stem cell-derived cerebral organoids from Alzheimer’s cases. BioRxiv

Schizophrenia— High Mobility Group Protein 1 and Dickkopf-Related Protein 1 in Schizophrenia and Treatment-Resistant Schizophrenia: Associations with Interleukin-6, Symptom Domains and Neurocognitive Impairments. Schizophrenia Bulletin

Autism Spectrum Disorder— Sporadic Autism Exomes Reveal a Highly Interconnected Protein Network of De Novo Mutations. Nature

Traumatic Brain Injury—Upregulation of WNT/beta-catenin expression is accompanied with vascular repair after traumatic brain injury. Journal of Cerebral Blood Flow & Metabolism

Fragile X Syndrome—Fragile X Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells. PLOS Genetics